Hip bone marrow lesions in asymptomatic and osteoarthritic adults: prevalence, risk factors and significance — ASN Events
  1. Schedule
  2. Free Communications - ANZBMS
  3. Hip bone marrow lesions in asymptomatic and osteoarthritic adults: prevalence, risk factors and significance

Hip bone marrow lesions in asymptomatic and osteoarthritic adults: prevalence, risk factors and significance (#210)

Luke P Dawson 1 , Yuanyuan Wang 1 , Anita Wluka 1 , Kim Bennell 2 , Flavia Cicuttini 1
  1. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, The Alfred Centre, Monash University, Melbourne, VIC, Australia
  2. Centre for Health, Exercise & Sports Medicine, School of Physiotherapy, University of Melbourne, Melbourne, VIC, Australia

Aims: Bone marrow lesions (BMLs) at the knee have an important role in the pathogenesis of osteoarthritis (OA), being associated with increased pain, accelerated cartilage loss, and increased risk of total knee replacement. However, data is limited for the role of BMLs at the hip. Therefore, this study aimed to determine the prevalence and associations of BMLs at the hip in an asymptomatic and an osteoarthritic population.

Methods: 142 asymptomatic and 19 participants with hip OA were recruited from existing cohorts. Hip magnetic resonance imaging was performed and used to assess femoral head BMLs, cartilage volume and bone area.

Results: The demographic characteristics of the asymptomatic versus the OA population were as follows: age 66.8+/-7.4 vs 59.5+/-7.6 yrs (p<0.001), % female 55.6% vs 57.9% (p=0.85), BMI 27.6+/-4.8 vs 27.2+/-4.8 kg/m2 (p=0.73). The prevalence of BMLs was 17.6% in the asymptomatic population and 63.2% in the OA population (p<0.001). BMLs were strongly associated with OA after adjusting for age, gender and BMI (odds ratio 5.32, 95% CI 1.78, 15.9, p=0.003). BMLs were associated with lower femoral head cartilage volume in the whole population (regression coefficient -245.7 mm3, 95% CI -455.5, -36.0, p=0.02). In the OA population, BMLs were also associated with lower femoral head cartilage volume (regression coefficient -426.6 mm3, 95% CI -855.2, 2.14, p=0.05) after adjusting for age, gender, BMI, femoral head bone area and hip OA (for analysis of the total population).

Conclusion: Femoral headBMLs are common in those with OA, but are also present in asymptomatic individuals with no clinical hip OA. They are associated with reduced hip cartilage volume. These findings suggest that BMLs at the hip may provide a novel target for the treatment and prevention of hip OA.