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Cardiomyocytes injection into infarcted murine heart improves heart function. (#393)

Irina Kulina 1 2 , Catherine Browne 1 2 , Chris Blair 3 , Paul Verma 4 , Michael Feneley 3 , Kerry Atkinson 1 2
  1. Mater Medical Research Institution, South Brisbane, QLD, Australia
  2. The University of Queensland, Brisbane, QLD, Australia
  3. Victor Chang Cardiac Research Institute, Sydney, NSW, Australia
  4. Monash Institute of Medical Research, Clayton, VIC, Australia

According to the Australian Bureau of Statistics diseases of the heart and blood vessels were identified as the underlying cause of 48,456 registered deaths in 2010 [1]. This accounted for 31.7% of all registered deaths. Ischaemic heart disease which includes angina and acute coronary syndromes including acute myocardial infarction (AMI),, represented a major proportion of these, accounting for 23,665 deaths (49%) [2]. In fact cardiovascular disease kills one Australian nearly every 11 minutes. l It is the commonest cause of death in the World.
Cell therapy represents a new approach to the treatment of severe ischemic heart disease. We and others have already demonstrated improvement in cardiac function by the intramyocardial injection of murine mesenchymal stromal cells (MSC) into acutely infarcted murine hearts [3,4]. The improvement, however, was of finite duration. In order to prolong the benefit seen with MSC injection, the current study explored the use of murine cardiomyocytes (CMs) given alone or in combination with MSCs and compared to the administration of MSCs alone. CMs administered alone improved cardiac function in mice after AMI.
We now plan to investigate the co-administration of MSCs and CMs administered to mice after AMI

  1. Australian Bureau of Statistics: http://www.abs.gov.au/ausstats/abs@.nsf/Products/D994DB9999C8E7B6CA2579C6000F6BB1?opendocument.
  2. Causes of death 2008: data sources and methods. Geneva: World Health Organization, 2010.
  3. Wang, C.C., C.H. Chen, W.W. Lin, S.M. Hwang, P.C. Hsieh, P.H. Lai, et al., Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction. Cardiovasc Res, 2008; 77(3): p. 515.
  4. Brooke, G., Cook, M., Blair, C.R., et al. Therapeutic applications of mesenchymal stromal cells. Seminars in Cell & Developmental Biology, 2007; 18(6): p. 846.